منابع مشابه
Regulation of antigenic variation in Giardia lamblia.
Antigenic variation, a clonal phenotypic variation developed by microorganisms, involves the permanent switching of homologous, antigenically different cell surface molecules. In pathogenic microorganisms, antigenic variation is often described as a mechanism to evade the host immune system and therefore is responsible for the generation of chronic and/or recurrent infections. However, antigeni...
متن کاملAntigenic variation of Giardia lamblia in vivo.
A single Giardia lamblia trophozoite can give rise in vitro to G. lamblia with varying surface antigens. To determine whether antigenic variation also occurs in vivo, gerbils were inoculated with defined G. lamblia clones and the surface antigens of the intestinal trophozoites were studied at different times during the infection. The proportion of monoclonal antibody 6E7-reacting trophozoites f...
متن کاملAntigenic variation of a cysteine-rich protein in Giardia lamblia
The WB isolate of Giardia lamblia expresses a cysteine-rich 170-kD surface antigen (CRP170) that undergoes antigenic variation. An (6E7), cytotoxic for isolates expressing CRP170, was used in another study to select antigenic variants from clones of the WB isolate of Giardia. CRP170 was replaced by surface-labeled bands ranging in size from approximately 50 to 170 kD. In this study, mAb 6E7 was...
متن کاملAntigenic variation in malaria
Parasite variability is a major factor in parasite survival strategies. Some parasites rely on random mutations to create variation, and if the mutation rate is high, as in HIV, this may suffice to create unsurmountable difficulties for the host. Other parasites augment variability by regularly replacing the antigens exposed to the host immune system. African trypanosomes (sleeping sickness) an...
متن کاملEvolution of Antigenic Variation
processes that shape genetic variability and evolutionary change.The causes of variability and change provide the basis for understanding why simple vaccines work well against some viruses, whereas complex vaccine strategies achieve only limited success against other viruses. The battle between host and parasite often comes down to the rates at which attacker and defender molecules bind or evad...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2009
ISSN: 1462-5814,1462-5822
DOI: 10.1111/j.1462-5822.2009.01367.x